World number two Rafa Nadal confirmed on Tuesday that he would not defend his U.S. Open crown this year at Flushing Meadows.
His announcement came as organisers released the singles entry list for the Grand Slam.
Spain’s Nadal had said in June that he had reservations about travelling to the U.S. amid the COVID-19 pandemic.
He joins women’s world number one Australian Ash Barty in skipping the tournament due to COVID-19 concerns.
“After many thoughts I have decided not to play at this year’s U.S. Open,” Nadal said on Twitter.
”The situation is very complicated worldwide, and the COVID-19 cases are increasing. It looks like we still don’t have control of it.
“We know that the reduced tennis calendar is barbaric this year after four months stopped with no play.
”I understand and thank everyone for the efforts they are putting in to make it happen. We have just seen the announcement of Madrid not being played this year.
“This is a decision I never wanted to take but I have decided to follow my heart this time and for the time being, I rather not travel.”
The Madrid Open, which was scheduled to take place from September 12 to 20, was cancelled on Tuesday due to the rise of COVID-19 cases in the Spanish capital.
The U.S. has the highest tally in the world with more than 4.7 million confirmed novel coronavirus cases and nearly 156,000 deaths, according to a Reuters tally.
World number one Novak Djokovic, a three-times champion in New York, headlines the men’s list along with last year’s runner-up Daniil Medvedev.
There are other top 10 players, including Dominic Thiem, Stefanos Tsitsipas and Alexander Zverev.
Swiss Roger Federer, a five-times U.S. Open champion, will also be absent after the 38-year-old was forced to undergo knee surgery in June which prematurely ended his 2020 season.
Nine of the top 10 women’s players, including 23-times Grand Slam champion Serena Williams and holder Bianca Andreescu, are on the entry list along with 2018 champion Naomi Osaka.
As many as 13 Grand Slam champions are in the women’s draw.
These include Romania’s Simona Halep, the reigning Wimbledon champion and 2018 French Open winner, and this year’s Australian Open champion American Sofia Kenin.
The United States Tennis Association (USTA) said eight additional wildcard entries would be selected in both the men’s and women’s fields.
Organisers said the seedings would be announced closer to the start of the tournament which is scheduled for August 31.
A number of players are also set to take part in the August 20 to 28 Western & Southern Open in New York, which serves as a warm-up event for the U.S. Open.